Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.49 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
| ▸ | CES1 | P23141 | 4/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.39 |
| ▸ | PPARD | Q03181 | 6/20 | 0.39 |
| ▸ | PPARA | Q07869 | 6/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19285352 | 0.93 | ENPP2 (0.42) | ENPP2CES2CES1CA1CA2 | |
| SCHEMBL7679582 | 0.81 | ENPP2 (0.52) | ENPP2CES2CES1AKR1B1GPR84 | |
| SCHEMBL3260172 | 0.79 | ENPP2 (0.50) | ENPP2CES2CES1AKR1B1GPR84 | |
| SCHEMBL11386544 | 0.79 | ENPP2 (0.55) | ENPP2CES2CES1GPR84PPARG | |
| SCHEMBL3802130 | 0.77 | ENPP2 (0.49) | ENPP2CES2CES1AKR1B1GPR84 | |
| SCHEMBL2473534 | 0.77 | ENPP2 (0.49) | ENPP2CES2CES1AKR1B1GPR84 | |
| SCHEMBL2473531 | 0.76 | ENPP2 (0.47) | ENPP2CES2CES1AKR1B1GPR84 | |
| SCHEMBL11580294 | 0.74 | CES2 (0.50) | CES2CES1AKR1B1GPR84PPARG | |
| SCHEMBL10622175 | 0.73 | ENPP2 (0.44) | ENPP2CES2CES1AKR1B1CA1 | |
| SCHEMBL29048050 | 0.73 | CES2 (0.52) | CES2CES1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882719-B1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMA CO LTD (JP) | 2001-05-16 | — | — | EP | claimed |
| US-6083955-A | HAVING A HIGH AFFINITY FOR DRUGS, ESPECIALLY ENDOSERINE RECEPTORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | claimed |
| EP-0882719-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-09 | — | — | EP | claimed |
| CN-109942595-B | Oxygen-bridged bicyclo- [2.2.1] -heptene compounds containing different functional side chain structures and preparation and application thereof | 武汉大学 | 2020-08-25 | — | — | CN | disclosed |
| CN-109942595-A | Oxygen bridge containing different functionalities side-chain structure is bicyclic-[2.2.1]-heptan vinyl compound and its preparation and application | 武汉大学 | 2019-06-28 | — | — | CN | disclosed |
| CN-108864127-A | A kind of oxygen bridge double-heptene sulfamide compound and the preparation method and application thereof containing different alkyl chain lengths | 武汉大学 | 2018-11-23 | — | — | CN | disclosed |
| US-9487517-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-11-08 | — | — | US | disclosed |
| US-20160016956-A1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-01-21 | — | — | US | disclosed |
| EP-2433940-B9 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| US-9169254-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-10-27 | — | — | US | disclosed |
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |
| US-6083955-A | HAVING A HIGH AFFINITY FOR DRUGS, ESPECIALLY ENDOSERINE RECEPTORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| US-6083955-A | HAVING A HIGH AFFINITY FOR DRUGS, ESPECIALLY ENDOSERINE RECEPTORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0882719-A4 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMA CO LTD (JP) | 1999-04-28 | — | — | EP | disclosed |
| CN-1204326-A | Arylvinylsulfonamide derivatives and pharmaceutical compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1999-01-06 | — | — | CN | disclosed |
| CN-1204326-A | Arylvinylsulfonamide derivatives and pharmaceutical compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1999-01-06 | — | — | CN | disclosed |
| EP-0882719-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |
| EP-0882719-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997022595-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-26 | — | — | WO | disclosed |
| US-3944502-A | Process for preparing microcapsules containing hydrophobic oil drops | FUJI PHOTO FILM CO., LTD. (JA) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016956-A1 | SPIROIMIDAZOLONE DERIVATIVE | WNK3, REN, SGK3 | ENPP2 4417/4885CES2 2589/4885CES1 3321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.