SCHEMBL8607237

SCHEMBL8607237

O=P(O)(Cc1cccc2ncc(P(=O)(O)O)n12)OO

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GGPS1 O95749 1/20 0.33
FDPS P14324 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8606805 0.86 PGK1 (0.39) GGPS1FDPS
SCHEMBL8605716 0.86 GGPS1 (0.32) GGPS1FDPS
SCHEMBL8608856 0.84 GGPS1 (0.32) GGPS1FDPS
SCHEMBL8609246 0.78 FDPS (0.35) GGPS1FDPS
SCHEMBL8606787 0.78 GGPS1 (0.35) GGPS1FDPS
SCHEMBL9753684 0.76 GGPS1 (0.35) GGPS1FDPS
SCHEMBL8608524 0.76 TBXAS1 (0.42) GGPS1FDPS
Methyl Alcohol SCHEMBL9753272 0.76 KDM4E (0.35) GGPS1FDPS
SCHEMBL8605872 0.76 FDPS (0.33) GGPS1FDPS
SCHEMBL8609564 0.74 GGPS1 (0.31) GGPS1FDPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0436831-A2 Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury G.D. Searle & Co. (US) 1991-07-17 EP claimed
WO-1991008211-A1 IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY G.D. SEARLE & CO. (US) 1991-06-13 WO claimed
US-5716964-A BRAIN DISORDERS; ANTIISCHEMIC AGENTS G.D. SEARLE & CO. (US) 1998-02-10 US disclosed
EP-0436831-A2 Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury G.D. Searle & Co. (US) 1991-07-17 EP disclosed
WO-1991008211-A1 IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY G.D. SEARLE & CO. (US) 1991-06-13 WO disclosed