Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8606282 | 0.81 | KDR (0.33) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL8605309 | 0.81 | TGFBR1 (0.47) | TGFBR1 | |
| SCHEMBL8606794 | 0.80 | KDR (0.48) | KDRFLT3 | |
| SCHEMBL8608912 | 0.74 | HPGD (0.37) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL14739009 | 0.73 | KDR (0.38) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL8607219 | 0.72 | PTGS1 (0.47) | KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL9753645 | 0.71 | NPC1 (0.47) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL9941639 | 0.71 | ALDH1A1 (0.44) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL30935693 | 0.71 | KDM4A (0.43) | KDRKDM4EALDH1A1GAAPKM | |
| SCHEMBL14756581 | 0.70 | KDM4E (0.43) | KDRKDM4EALDH1A1GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| US-5716964-A | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | G.D. SEARLE & CO. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0436831-A2 | Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |