Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PRCP | P42785 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501720 | 0.85 | ATM (0.76) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL5350446 | 0.84 | ATM (0.74) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL14369843 | 0.84 | ATM (0.74) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL11937432 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL13891742 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL11175977 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL501945 | 0.78 | ATM (0.73) | ALDH1A1KMT2AGAAATML3MBTL1 | |
| SCHEMBL16401785 | 0.78 | GAA (0.58) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL1873403 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KMT2AMAPTGAAATM | |
| SCHEMBL27467014 | 0.76 | KDM4E (0.63) | ALDH1A1KMT2AMAPTGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840614-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1996041638-A1 | CALPAIN INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1996-12-27 | — | — | WO | disclosed |