Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6427442 | 1.00 | LMNA (0.55) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL9276855 | 1.00 | LMNA (0.55) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6427034 | 1.00 | LMNA (0.55) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL14471579 | 1.00 | LMNA (0.55) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL8608960 | 1.00 | LMNA (0.55) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL28736297 | 0.93 | LMNA (0.63) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL28736296 | 0.93 | LMNA (0.63) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL29615078 | 0.91 | ALDH1A1 (0.50) | LMNAHPGDALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL29614989 | 0.91 | NPC1 (0.56) | LMNAHPGDALDH1A1TP53HDAC1 | |
| SCHEMBL29614952 | 0.91 | ALDH1A1 (0.56) | LMNAHPGDALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817867-A | Reduction and resolution methods for the preparation of compounds useful as intermediates for preparing taxanes | BRISTOL-MYERS SQUIBB CO. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5602272-A | Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |