Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895820 | 0.83 | ACE (0.41) | CTSKCTSLCTSBCTSSREN | |
| SCHEMBL8613299 | 0.79 | FOLH1 (0.41) | FOLH1 | |
| SCHEMBL8610410 | 0.72 | FOLH1 (0.40) | MMP1MMP2MMP8FOLH1 | |
| SCHEMBL8608851 | 0.72 | FOLH1 (0.40) | MMP1MMP2MMP8FOLH1 | |
| SCHEMBL8612047 | 0.71 | FOLH1 (0.37) | FOLH1 | |
| SCHEMBL8608760 | 0.68 | FOLH1 (0.44) | MMP1MMP2MMP8MMP3FOLH1 | |
| SCHEMBL27630987 | 0.65 | TDP1 (0.46) | MMP1MMP2MMP8 | |
| SCHEMBL3605562 | 0.64 | MMP1 (0.45) | MMP1MMP2MMP8MMP3CTSK | |
| SCHEMBL23241332 | 0.64 | L3MBTL1 (0.44) | MMP1MMP2MMP8MMP3 | |
| SCHEMBL8498746 | 0.64 | L3MBTL1 (0.44) | MMP1MMP2MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |