Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895314 | 0.83 | PPARG (0.36) | ACETSHR | |
| SCHEMBL8608764 | 0.83 | MMP1 (0.39) | MMP13CTSKCTSLCTSBCTSS | |
| SCHEMBL8898654 | 0.80 | ACE (0.45) | ACEMMP13HPGDALDH1A1NPC1 | |
| SCHEMBL8896159 | 0.80 | ACE (0.45) | ACEMMP13HPGDALDH1A1NPC1 | |
| SCHEMBL8897474 | 0.78 | PPARG (0.36) | ACEHPGDTSHR | |
| SCHEMBL8895815 | 0.76 | DPP4 (0.45) | ACEMMP13CTSKCTSLCTSB | |
| SCHEMBL8896829 | 0.69 | PPARG (0.48) | HPGDALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL8895899 | 0.68 | ABHD6 (0.49) | ACEALDH1A1NPC1GAA | |
| SCHEMBL23879162 | 0.66 | CTSK (0.52) | CTSKCTSLCTSBCTSSHPGD | |
| SCHEMBL23879171 | 0.66 | CTSK (0.52) | CTSKCTSLCTSBCTSSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |