Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486015 | 0.83 | OPRL1 (0.48) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8612151 | 0.83 | OPRL1 (0.48) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8609511 | 0.81 | OPRL1 (0.49) | OPRL1OPRM1OPRD1OPRK1CCNE2 | |
| SCHEMBL9395606 | 0.81 | OPRL1 (0.48) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8612024 | 0.81 | OPRL1 (0.48) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8609291 | 0.80 | OPRL1 (0.48) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8611525 | 0.79 | GRIK1 (0.57) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8611557 | 0.78 | OPRM1 (0.54) | OPRL1OPRM1SIRT2OPRD1OPRK1 | |
| SCHEMBL8611567 | 0.78 | OPRL1 (0.47) | OPRL1OPRM1OPRD1OPRK1CCNE2 | |
| SCHEMBL8611345 | 0.77 | GRIK1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852017-A | 2,3(1H,4H)-quinoxalinediones | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-22 | — | — | US | disclosed |
| EP-0572852-B1 | Quinoxalin-2,3(1H,4H)-diones used as medicine | BASF AG (DE) | 1998-10-21 | — | — | EP | disclosed |
| US-5714489-A | 2,3(1H,4H)quinoxalinedione | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-03 | — | — | US | disclosed |
| EP-0572852-A1 | Quinoxalin-2,3(1H,4H)-diones used as medicine | BASF Aktiengesellschaft (DE) | 1993-12-08 | — | — | EP | disclosed |