Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.56 |
| ▸ | GRM5 | P41594 | 10/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239831 | 0.83 | NAMPT (0.66) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL31227423 | 0.82 | GRM1 (0.48) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL19989639 | 0.81 | NAMPT (0.67) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL8263464 | 0.80 | SCD5 (0.48) | SCD5ABCB1ABCG2USP30 | |
| SCHEMBL2357493 | 0.79 | GPR119 (0.57) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL31379931 | 0.79 | GRM1 (0.58) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL2811392 | 0.79 | PDK4 (0.60) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL8263742 | 0.77 | PKM (0.46) | SCD5ABCB1ABCG2USP30 | |
| SCHEMBL30014227 | 0.76 | PDK4 (0.56) | GRM1GRM5PDK4NAMPTHTR6 | |
| SCHEMBL902871 | 0.76 | PDK4 (0.56) | GRM1GRM5PDK4NAMPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712285-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1998-01-27 | — | — | US | disclosed |