Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fipamezole SCHEMBL935549 | 0.84 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1B | |
| Fipamezole SCHEMBL3901401 | 0.83 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8613975 | 0.82 | KDM4E (0.30) | — | |
| Atipamezole SCHEMBL31147780 | 0.81 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL7640608 | 0.80 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL4626063 | 0.80 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8616108 | 0.80 | ADRA2A (0.32) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8611497 | 0.80 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8613817 | 0.79 | PNMT (0.41) | ADRA2AADRA2BADRA2CADRA1B | |
| Fipamezole SCHEMBL9354688 | 0.76 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618906-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | JUVANTIA PHARMA LTD OY (FI) | 1998-04-22 | — | — | EP | disclosed |
| US-5498623-A | MULTISTAGE REACTION FOR HALOGENATION OF COMPOUNDS, NITRATION, REDUCTION AND CONVERSION TO DIAZONIUM SALT THEN HALOGENATION FOR COGNITIVE DISORDERS | ORION-YHTYMA OY (FI) | 1996-03-12 | — | — | US | disclosed |
| EP-0618906-A1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ANTII SAKARI HAAPALINNA (FI) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013074-A1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Orion-Yhtymä Oy (FI) | 1993-07-08 | — | — | WO | disclosed |