SCHEMBL4626063

SCHEMBL4626063

CCC1(c2c[nH]cn2)Cc2cc(F)c(F)cc2C1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 2/20 0.40
ADRA2B P18089 2/20 0.40
ADRA2C P18825 2/20 0.40
ADRA1B P35368 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616157 0.90 ADRA2A (0.36) ADRA2AADRA2BADRA2CADRA1B
SCHEMBL8611497 0.90 ADRA2A (0.36) ADRA2AADRA2BADRA2CADRA1B
Fipamezole SCHEMBL935549 0.86 ADRA2A (0.57) ADRA2AADRA2BADRA2CADRA1B
Fipamezole SCHEMBL1271449 0.86 ADRA2A (0.57) ADRA2AADRA2BADRA2CADRA1B
SCHEMBL8610760 0.85 PGR (0.35) ADRA2AADRA2BADRA2CADRA1B
SCHEMBL7640608 0.85 ADRA2A (0.35) ADRA2AADRA2BADRA2CADRA1B
Fipamezole SCHEMBL3901401 0.85 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1B
Atipamezole SCHEMBL881064 0.81 ADRA2A (0.51) ADRA2AADRA2BADRA2CADRA1B
SCHEMBL7642900 0.80 ADRA2A (0.40) ADRA2AADRA2BADRA2CADRA1B
SCHEMBL8610304 0.80 ADRA2A (0.40) ADRA2AADRA2BADRA2CADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1610771-B1 USE OF AN ALPHA2-ADRENOCEPTOR ANTAGONIST FOR THE TREATMENT OF EPILEPSY ORION CORP (FI) 2008-12-03 EP claimed
JP-3276371-B2 2002-04-22 JP claimed
EP-0618906-B1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE JUVANTIA PHARMA LTD OY (FI) 1998-04-22 EP claimed
US-5498623-A MULTISTAGE REACTION FOR HALOGENATION OF COMPOUNDS, NITRATION, REDUCTION AND CONVERSION TO DIAZONIUM SALT THEN HALOGENATION FOR COGNITIVE DISORDERS ORION-YHTYMA OY (FI) 1996-03-12 US claimed
EP-0618906-A1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE ANTII SAKARI HAAPALINNA (FI) 1994-10-12 EP claimed
WO-1993013074-A1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE Orion-Yhtymä Oy (FI) 1993-07-08 WO claimed
EP-1610771-B1 USE OF AN ALPHA2-ADRENOCEPTOR ANTAGONIST FOR THE TREATMENT OF EPILEPSY ORION CORP (FI) 2008-12-03 EP disclosed
US-20080207719-A1 Treatment of Epilepsy ORION CORPORATION (FI) 2008-08-28 US disclosed
EP-1333828-B1 PREVENTION OF DEVELOPMENT OF DYSKINESIAS ORION CORP (FI) 2008-07-02 EP disclosed
US-20060058364-A1 Treatment of dependence and dependence related withdrawal symptoms ORION CORPORATION (FI) 2006-03-16 US disclosed
EP-1610771-A2 USE OF AN ALPHA2-ADRENOCEPTOR ANTAGONIST FOR THE TREATMENT OF EPILEPSY ORION CORPORATION (FI) 2006-01-04 EP disclosed
WO-2004089349-A2 USE OF AN ALPHA2-ADRENOCEPTOR ANTAGONIST FOR THE TREATMENT OF EPILEPSY ORION CORPORATION (FI) 2004-10-21 WO disclosed
US-20040039041-A1 Prevention of development of dyskinesias ORION CORPORATION (FI) 2004-02-26 US disclosed
US-20020115704-A1 Treatment method ORION CORPORATION (FI) 2002-08-22 US disclosed
WO-2002047684-A1 METHOF FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION ORION CORPORATION (FI) 2002-06-20 WO disclosed
WO-2002039991-A2 PREVENTION OF DEVELOPMENT OF DYSKINESIAS ORION CORPORATION (FI) 2002-05-23 WO disclosed
EP-0618906-B1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE JUVANTIA PHARMA LTD OY (FI) 1998-04-22 EP disclosed
US-5498623-A MULTISTAGE REACTION FOR HALOGENATION OF COMPOUNDS, NITRATION, REDUCTION AND CONVERSION TO DIAZONIUM SALT THEN HALOGENATION FOR COGNITIVE DISORDERS ORION-YHTYMA OY (FI) 1996-03-12 US disclosed
EP-0618906-A1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE ANTII SAKARI HAAPALINNA (FI) 1994-10-12 EP disclosed
WO-1993013074-A1 SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE Orion-Yhtymä Oy (FI) 1993-07-08 WO disclosed