Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611873 | 0.83 | MAPT (0.73) | MAPTKMT2AMEN1TDP1TP53 | |
| SCHEMBL8654803 | 0.83 | ABCB1 (0.72) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL7713577 | 0.82 | MAPT (1.00) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL8613867 | 0.82 | MAPT (0.82) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL3641483 | 0.81 | MAPT (0.62) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL11481090 | 0.81 | TSHR (0.68) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL8638802 | 0.81 | ABCB1 (0.85) | KMT2AGAATP53THRBABCB1 | |
| SCHEMBL8702992 | 0.79 | MAPT (0.68) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL11810228 | 0.79 | MAPT (0.65) | MAPTKMT2AMEN1TDP1GAA | |
| SCHEMBL8637458 | 0.79 | L3MBTL1 (0.70) | MAPTKMT2AMEN1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833639-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| US-5614526-A | IN TREATING DISORDERS OF THE DOPAMINE SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996041630-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-27 | — | — | WO | disclosed |