Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.49 |
| ▸ | LAP3 | P28838 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896352 | 1.00 | FOLH1 (0.49) | FOLH1LAP3HRH4HRH3MAPT | |
| SCHEMBL8610371 | 1.00 | FOLH1 (0.49) | FOLH1LAP3HRH4HRH3MAPT | |
| SCHEMBL8896358 | 1.00 | FOLH1 (0.49) | FOLH1LAP3HRH4HRH3MAPT | |
| SCHEMBL7303529 | 0.80 | FOLH1 (0.51) | FOLH1LAP3MAPTCTSKALDH1A1 | |
| SCHEMBL8897285 | 0.78 | PPARG (0.45) | CYP2C19ALDH1A1 | |
| SCHEMBL8897280 | 0.78 | PPARG (0.45) | CYP2C19ALDH1A1 | |
| SCHEMBL24261161 | 0.77 | ALOX15 (0.41) | HRH4HRH3MAPTCYP2D6CYP2C19 | |
| SCHEMBL12654925 | 0.73 | HRH4 (0.42) | HRH4HRH3MAPTCYP2D6CYP2C19 | |
| SCHEMBL12872128 | 0.73 | HRH4 (0.42) | HRH4HRH3MAPTCYP2D6CYP2C19 | |
| SCHEMBL17793930 | 0.73 | HRH4 (0.38) | HRH4HRH3MAPTCTSKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |