Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897285 | 1.00 | PPARG (0.45) | PPARGPPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8898668 | 0.79 | CTSL (0.41) | MEN1KMT2ASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL8896829 | 0.78 | PPARG (0.48) | PPARGPPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8895944 | 0.78 | CTSL (0.45) | MEN1KMT2ASMN1; SMN2TSHRCYP2C9 | |
| SCHEMBL8610377 | 0.78 | FOLH1 (0.49) | ALDH1A1CYP2C19 | |
| SCHEMBL8896352 | 0.78 | FOLH1 (0.49) | ALDH1A1CYP2C19 | |
| SCHEMBL8610371 | 0.78 | FOLH1 (0.49) | ALDH1A1CYP2C19 | |
| SCHEMBL8896358 | 0.78 | FOLH1 (0.49) | ALDH1A1CYP2C19 | |
| SCHEMBL8895311 | 0.77 | CTSL (0.46) | PPARGPPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8896571 | 0.77 | CTSL (0.46) | PPARGPPARAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |