Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MASP2 | O00187 | 1/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546101 | 0.73 | EGLN1 (0.51) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL7018102 | 0.73 | BCHE (0.50) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL17054456 | 0.73 | EGLN1 (0.51) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL25429336 | 0.73 | SMN1; SMN2 (0.56) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL18321301 | 0.73 | EGLN1 (0.62) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL11030252 | 0.72 | BCHE (0.49) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| Hydrochloric Acid SCHEMBL18321261 | 0.72 | EGLN1 (0.60) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL3389271 | 0.72 | BCHE (0.56) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL7027117 | 0.70 | HTR3A (0.53) | ALDH1A1MEN1KMT2AMASP2NUDT1 | |
| SCHEMBL3591723 | 0.69 | HTR3A (0.51) | ALDH1A1MEN1KMT2AMASP2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1802303-B1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2011-11-02 | — | — | EP | disclosed |
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | disclosed |
| EP-1723138-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | BASILEA PHARMACEUTICA AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | EBERLE MARTIN | 2008-11-20 | — | — | US | disclosed |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | disclosed |
| US-7423157-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2008-09-09 | — | — | US | disclosed |
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-07-19 | — | — | US | disclosed |
| EP-1802303-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2007-07-04 | — | — | EP | disclosed |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-03-22 | — | — | US | disclosed |
| EP-1723138-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | Basilea Pharmaceutica AG (CH) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006034003-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005077939-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | BASILEA PHARMACEUTICA AG (CH) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | SNCA, PARK7, HTT | ALDH1A1 171/4885MEN1 4741/4885KMT2A 1570/4885 |
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | ALDH1A1 1220/4885MEN1 2023/4885KMT2A 2445/4885 |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | ALDH1A1 1220/4885MEN1 2023/4885KMT2A 2445/4885 |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | BAX, BCL2, BAD | ALDH1A1 1220/4885MEN1 2023/4885KMT2A 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.