Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | GHSR | Q92847 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614292 | 0.93 | KCNH2 (0.52) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL9148247 | 0.84 | KCNH2 (0.50) | KCNH2TACR1MEN1KMT2ACYP3A4 | |
| SCHEMBL8610976 | 0.82 | KCNH2 (0.52) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL8611930 | 0.81 | MAPK1 (0.55) | KCNH2TACR1MEN1KMT2ACYP3A4 | |
| SCHEMBL7751327 | 0.81 | SLC6A3 (0.54) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7754352 | 0.81 | KCNH2 (0.60) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL8617368 | 0.81 | KCNH2 (0.52) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7544797 | 0.80 | SLC6A3 (0.53) | MEN1KMT2ACYP3A4CYP2D6ADORA3 | |
| SCHEMBL8610943 | 0.79 | KCNH2 (0.51) | KCNH2MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL8616693 | 0.78 | HTR2A (0.50) | KCNH2TACR1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549796-B1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEM IND INC (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |