Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751327 | 0.91 | SLC6A3 (0.54) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL8611835 | 0.90 | DRD3 (0.49) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| Hydrochloric Acid SCHEMBL7544797 | 0.90 | SLC6A3 (0.53) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL8611930 | 0.89 | MAPK1 (0.55) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL7754348 | 0.85 | SLC6A3 (0.52) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL8614302 | 0.85 | KCNH2 (0.48) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL9145616 | 0.82 | DRD3 (0.49) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL8611936 | 0.80 | SLC6A3 (0.58) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL8612001 | 0.80 | SLC6A3 (0.59) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL7754343 | 0.79 | CYP3A4 (0.53) | HTR2AADRA1AHRH1DRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549796-B1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEM IND INC (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0612738-A1 | Diphenylpiperazine derivative and drug for circulatory organ containing the same | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1994-08-31 | — | — | EP | disclosed |
| EP-0549796-A1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEMICAL INDUSTRIES INC (JP) | 1993-07-07 | — | — | EP | disclosed |