SCHEMBL8611275

SCHEMBL8611275

CC(C)=Cc1cccc(C(=O)O)c1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
KDM4E B2RXH2 3/20 0.53
HPGD P15428 3/20 0.53
HSD17B10 Q99714 2/20 0.53
ALB P02768 1/20 0.48
MMP2 P08253 1/20 0.48
HNF4A P41235 1/20 0.46
HMGB1 P09429 2/20 0.42
KMT2A Q03164 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
ALOX15 P16050 1/20 0.41
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CA7 P43166 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357851 0.82 ERN1 (0.57) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL348314 0.82 ERN1 (0.57) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL2401353 0.82 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10HMGB1
Water SCHEMBL17627596 0.81 ERN1 (0.55) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL5440903 0.80 ERN1 (0.44) ALDH1A1KDM4EHPGDHSD17B10MMP2
SCHEMBL11130591 0.78 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL11130587 0.78 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL21457181 0.77 TRPA1 (0.50) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL1815797 0.77 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10ALB
SCHEMBL5463687 0.77 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0796861-B1 Silated derivatives of salicilic acid with desquamative properties OREAL (FR) 1998-04-08 EP disclosed
EP-0796861-A1 Silated derivatives of salicilic acid with desquamative properties L'OREAL (FR) 1997-09-24 EP disclosed
US-5563148-A BICYCLIC ESTERS OR AMIDES; USED IN TREATING MIGRAINE, EMESIS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA OR ANXIETY IN MAMMALS ELI LILLY AND COMPANY (US) 1996-10-08 US disclosed