Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.40 |
| ▸ | PARP1 | P09874 | 6/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.34 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860711 | 0.86 | CDK5 (0.36) | PARP1PARP3PARP16 | |
| SCHEMBL1803562 | 0.83 | USP30 (0.42) | DPP4 | |
| SCHEMBL1803563 | 0.83 | USP30 (0.42) | DPP4 | |
| SCHEMBL861429 | 0.82 | PARP3 (0.50) | PARP1PARP3HSD11B1 | |
| SCHEMBL1805265 | 0.82 | TBK1 (0.31) | PARP3PARP16 | |
| SCHEMBL1805261 | 0.82 | TBK1 (0.31) | PARP3PARP16 | |
| SCHEMBL1805263 | 0.82 | TBK1 (0.31) | PARP3PARP16 | |
| SCHEMBL2599154 | 0.81 | RORC (0.37) | PARP1PARP3 | |
| SCHEMBL861829 | 0.81 | HDAC2 (0.40) | PARP1 | |
| SCHEMBL2598124 | 0.81 | KMT2A (0.41) | DPP4PARP1F7F3PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |