Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524297 | 1.00 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL8489623 | 0.89 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL8489625 | 0.89 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL8648249 | 0.80 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL8648245 | 0.80 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL9347018 | 0.74 | POLB (0.63) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL4811982 | 0.74 | POLB (0.63) | POLBKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL29687970 | 0.74 | POLB (0.67) | POLBKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28402577 | 0.74 | ALDH1A1 (0.65) | POLBKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL12793245 | 0.73 | POLB (0.88) | POLBKMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | claimed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |