Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27277978 | 1.00 | OPRM1 (0.39) | OPRM1OPRL1OPRK1CCR2ALDH1A1 | |
| SCHEMBL11309793 | 0.76 | KDM1A (0.45) | OPRM1OPRL1OPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL28224382 | 0.73 | MEN1 (0.40) | OPRM1OPRL1OPRK1CCR2ALDH1A1 | |
| SCHEMBL6404032 | 0.70 | OPRM1 (0.41) | OPRM1OPRL1OPRK1CCR2ALDH1A1 | |
| SCHEMBL11470470 | 0.69 | OPRM1 (0.41) | OPRM1OPRL1OPRK1ALDH1A1LMNA | |
| Diethylamine SCHEMBL11101906 | 0.68 | KDM1A (0.36) | OPRM1OPRL1OPRK1CCR2MMP1 | |
| SCHEMBL11459652 | 0.65 | OPRL1 (0.42) | OPRM1OPRL1OPRK1CCR2SIGMAR1 | |
| SCHEMBL498014 | 0.64 | OPRM1 (0.50) | OPRM1OPRL1OPRK1ALDH1A1LMNA | |
| SCHEMBL30312220 | 0.64 | OPRM1 (0.50) | OPRM1OPRL1OPRK1ALDH1A1LMNA | |
| SCHEMBL30550560 | 0.64 | CCR2 (0.33) | OPRM1OPRL1OPRK1CCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827855-A | ANTICHOLESTEROL AGENTS TREATING CARDIOVASCULAR DISORDERS; ENZYME INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-10-27 | — | — | US | disclosed |
| CN-1039642-C | Derivative of hexahydronaphthalene ester, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-09-02 | — | — | CN | disclosed |
| EP-0605230-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5451688-A | Inhibit biosynthesis of cholesterol | SANKYO COMPANY, LIMITED (JP) | 1995-09-19 | — | — | US | disclosed |
| CN-1094707-A | Hexahydro-naphthalene ester derivative, their preparation and their application aspect treatment | SANKYO CO (JP) | 1994-11-09 | — | — | CN | disclosed |
| EP-0605230-A1 | Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-07-06 | — | — | EP | disclosed |