Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404032 | 0.69 | OPRM1 (0.41) | OPRL1OPRM1OPRK1SIGMAR1BACE1 | |
| SCHEMBL27277978 | 0.65 | OPRM1 (0.39) | OPRL1OPRM1OPRK1SIGMAR1MMP1 | |
| SCHEMBL8612396 | 0.65 | OPRM1 (0.39) | OPRL1OPRM1OPRK1SIGMAR1MMP1 | |
| SCHEMBL11245064 | 0.64 | LMNA (0.38) | OPRL1OPRM1OPRK1BACE1MMP2 | |
| SCHEMBL1366868 | 0.64 | OPRL1 (0.41) | OPRL1OPRM1OPRK1BACE1CCR2 | |
| SCHEMBL10154510 | 0.63 | HSD11B1 (0.45) | OPRL1OPRM1OPRK1BACE1 | |
| SCHEMBL13330631 | 0.63 | OPRL1 (0.37) | OPRL1OPRM1OPRK1SIGMAR1BACE1 | |
| SCHEMBL10154499 | 0.63 | BACE1 (0.45) | OPRL1OPRM1OPRK1BACE1 | |
| SCHEMBL13398182 | 0.63 | — | — | |
| SCHEMBL30312220 | 0.63 | OPRM1 (0.50) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4191771-A | NARCOTIC ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-03-04 | — | — | US | disclosed |
| US-4175197-A | 1,3,4-Trisubstituted-4-aryl-1,4,5,6-tetra-hydropyridines | ELI LILLY AND COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4115400-A | 1-Azoniabicyclo[3.1.0]hexanes | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4081450-A | 1,3,4-Trisubstituted-4-arylpiperidines and their preparation | ELI LILLY AND COMPANY (US) | 1978-03-28 | — | — | US | disclosed |