SCHEMBL8612474

SCHEMBL8612474

[CH2]c1ccc(NC(=O)CCCCCCCCC(=O)N(C)c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.51
NPC1 O15118 1/20 0.51
MAPT P10636 1/20 0.51
ALOX15 P16050 1/20 0.51
NFKB1 P19838 1/20 0.51
MAPK1 P28482 1/20 0.51
RAB9A P51151 1/20 0.51
NFKB2 Q00653 1/20 0.51
RELA Q04206 1/20 0.51
MCL1 Q07820 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HDAC4 P56524 17/20 0.50
HDAC1 Q13547 17/20 0.50
HDAC11 Q96DB2 17/20 0.50
HDAC8 Q9BY41 17/20 0.50
HDAC6 Q9UBN7 17/20 0.50
HDAC5 Q9UQL6 17/20 0.50
HDAC7 Q8WUI4 16/20 0.50
HDAC9 Q9UKV0 16/20 0.50
HDAC3 O15379 16/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8585476 0.83 HDAC4 (0.70) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL7109424 0.80 ALDH1A1 (0.59) ALDH1A1NPC1MAPTALOX15NFKB1
SCHEMBL8587363 0.79 HDAC1 (0.75) ALDH1A1NPC1RAB9ASMN1; SMN2HDAC4
SCHEMBL10281559 0.79 HDAC6 (0.56) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL23054823 0.78 HDAC8 (0.66) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL23054864 0.78 HDAC8 (0.66) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL23055025 0.78 HDAC8 (0.66) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL27574174 0.78 LMNA (0.47) ALDH1A1HDAC4HDAC1HDAC11HDAC8
SCHEMBL23054822 0.78 HDAC8 (0.66) HDAC4HDAC1HDAC11HDAC8HDAC6
SCHEMBL8010609 0.77 ALOX5 (0.60) ALDH1A1NPC1MAPTALOX15NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998031689-A1 NOVEL MIXED BENZENE ACID DERIVATIVES, METHOD FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ADIR ET COMPAGNIE (FR) 1998-07-23 WO disclosed