SCHEMBL8612787

SCHEMBL8612787

Cc1nc(C)c(C(=O)c2ccoc2)o1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 8/20 0.46
MAPT P10636 6/20 0.42
ALDH1A1 P00352 8/20 0.41
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 5/20 0.40
POLB P06746 5/20 0.40
USP2 O75604 4/20 0.40
HTT P42858 3/20 0.40
LMNA P02545 3/20 0.40
TSHR P16473 3/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
TRPA1 O75762 1/20 0.37
TDP1 Q9NUW8 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
ALOX15 P16050 1/20 0.36
MCL1 Q07820 1/20 0.36
ESR2 Q92731 1/20 0.36
CYP3A4 P08684 1/20 0.36
ADORA2A P29274 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616481 0.81 HSD17B10 (0.37) HSD17B10MAPTALDH1A1HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL8614794 0.79 HSD17B10 (0.36) HSD17B10MAPTALDH1A1HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL8618974 0.78 HSD17B10 (0.38) HSD17B10MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL27432878 0.76 HSD17B10 (0.47) HSD17B10MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL27460940 0.74 ALDH1A1 (0.42) HSD17B10MAPTALDH1A1SMN1; SMN2POLB
SCHEMBL8866037 0.72 TRPA1 (0.48) MAPTALDH1A1HPGDMEN1KMT2A
SCHEMBL8615006 0.71 GAA (0.47) ALDH1A1POLBLMNAADORA2AADORA1
SCHEMBL286999 0.68 HSD17B10 (0.47) HSD17B10MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL277930 0.68
SCHEMBL28321436 0.68 ALDH1A1 (0.64) ALDH1A1HPGDSMN1; SMN2HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5731335-A NERVOUS SYSTEM DISORDERS; STROKE; ANTIISCHEMIC AGENTS; COGNITION ACTIVATORS ASTRA AKTIEBOLAG (SE) 1998-03-24 US disclosed
US-5607956-A TREATMENT OF NEURODEGENERATIVE DISORDERS SUCH AS CEREBRAL ISCHEMIA, ALZHEIMER'S DISEASE ASTRA AKTIEBOLAG (SE) 1997-03-04 US disclosed
CN-1126994-A Novel (1-heteroazolyl-1-heterocyclyl) alkane derivatives and their use as neuroprotective agents ASTRA AB (SE) 1996-07-17 CN disclosed
EP-0707584-A1 NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS Astra Aktiebolag (SE) 1996-04-24 EP disclosed
WO-1995001979-A1 NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS ASTRA AKTIEBOLAG (SE) 1995-01-19 WO disclosed