Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614999 | 0.90 | P2RX7 (0.34) | TSHRUSP2ALDH1A1SMN1; SMN2P2RX7 | |
| SCHEMBL8615386 | 0.81 | ADRA1A (0.45) | USP2ALDH1A1P2RX7KMT2A | |
| SCHEMBL8613101 | 0.79 | ACE (0.38) | ACETSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8761596 | 0.76 | P2RX7 (0.46) | ACEUSP2ALDH1A1P2RX7KMT2A | |
| SCHEMBL7826338 | 0.75 | ACE (0.39) | ACETSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL10754807 | 0.75 | ACE (0.39) | ACETSHRUSP2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8895919 | 0.74 | ACE (0.41) | ACETSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8762017 | 0.73 | MEN1 (0.57) | ACEUSP2ALDH1A1P2RX7KMT2A | |
| SCHEMBL29833530 | 0.73 | MEN1 (0.57) | ACEUSP2ALDH1A1P2RX7KMT2A | |
| SCHEMBL8898135 | 0.72 | EPHX1 (0.41) | USP2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |