Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | DHODH | Q02127 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TACR3 | P29371 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788464 | 1.00 | MEN1 (0.71) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL8618627 | 0.87 | ALDH1A1 (0.65) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL19508777 | 0.86 | TACR3 (0.65) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL8324531 | 0.86 | MEN1 (0.77) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL5526710 | 0.85 | CYP2C9 (0.69) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL27810072 | 0.84 | KMT2A (0.69) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL18746 | 0.84 | KDM4E (0.83) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL29359819 | 0.84 | KDM4E (0.83) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL19520848 | 0.83 | MEN1 (0.73) | MEN1KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL8616465 | 0.83 | CYP2C9 (0.61) | MEN1KMT2APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574530-B | ACC inhibitor and medical application thereof | 徐州医科大学 | 2022-07-26 | — | — | CN | disclosed |
| CN-111574530-A | ACC inhibitor and medical application thereof | 徐州医科大学 | 2020-08-25 | — | — | CN | disclosed |
| US-7482458-B2 | Quinoline derivatives | SMITHKLINE BEECHAM FARMACEUTICA S.P.A. (IT) | 2009-01-27 | — | — | US | disclosed |
| US-7482458-B2 | Quinoline derivatives | SMITHKLINE BEECHAM FARMACEUTICA S.P.A. (IT) | 2009-01-27 | — | — | US | disclosed |
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |