Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.66 |
| ▸ | DHODH | Q02127 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532004 | 0.90 | KDM4E (0.69) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8231325 | 0.89 | DHODH (0.64) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL30690053 | 0.89 | PLA2G2A (0.73) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8172197 | 0.89 | DHODH (0.61) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8616465 | 0.84 | CYP2C9 (0.61) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL10761434 | 0.84 | NPC1 (0.54) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL245078 | 0.83 | PLA2G2A (0.81) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4189945 | 0.82 | TACR3 (0.74) | PDE10ADHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8620862 | 0.82 | ALDH1A1 (0.54) | DHODHKDM4EALDH1A1TP53CYP2C19 | |
| SCHEMBL29788461 | 0.81 | DHODH (0.81) | DHODHKDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| US-4711890-A | TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-12-08 | — | — | US | disclosed |
| US-4684652-A | TREATING ANXIETY OR CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-08-04 | — | — | US | disclosed |