Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TDO2 | P48775 | 3/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614038 | 0.89 | PDE10A (0.39) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8616478 | 0.89 | PDE10A (0.39) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8616318 | 0.88 | BACE1 (0.41) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8619262 | 0.88 | BACE1 (0.41) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8619171 | 0.86 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL8617718 | 0.86 | PDE10A (0.56) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8620632 | 0.86 | HPGD (0.44) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8614767 | 0.85 | PDE10A (0.36) | PDE10AMAPTHPGDALDH1A1KDM4E | |
| SCHEMBL8614881 | 0.84 | TDO2 (0.43) | PDE10AMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8617947 | 0.84 | MEN1 (0.43) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |