Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.32 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.32 |
| ▸ | GLS2 | Q9UI32 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621126 | 0.87 | ALOX5 (0.44) | ALDH1A1ALOX5PRKCDPRKCAPDCD4 | |
| SCHEMBL8616293 | 0.87 | ALOX5 (0.44) | ALDH1A1ALOX5PRKCDPRKCAPDCD4 | |
| SCHEMBL8616623 | 0.78 | HDAC8 (0.42) | ALDH1A1L3MBTL1KMT2AFAAH | |
| SCHEMBL8614506 | 0.76 | CYP2C19 (0.41) | PDCD4 | |
| SCHEMBL1954978 | 0.74 | ALDH1A1 (0.46) | ALDH1A1PRSS1PRSS2PRSS3 | |
| SCHEMBL1838374 | 0.74 | ALDH1A1 (0.46) | ALDH1A1PRSS1PRSS2PRSS3 | |
| SCHEMBL1834481 | 0.74 | ALDH1A1 (0.46) | ALDH1A1PRSS1PRSS2PRSS3 | |
| SCHEMBL8621353 | 0.73 | ALDH1A1 (0.39) | ALDH1A1ZDHHC7MEN1MAPTKMT2A | |
| SCHEMBL1837181 | 0.72 | ALDH1A1 (0.44) | ALDH1A1PRSS1PRSS2PRSS3POLB | |
| SCHEMBL9745643 | 0.70 | PDCD4 (0.38) | ALDH1A1L3MBTL1POLBPDCD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525002-B1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0525002-A4 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS CA?2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0525002-A1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991016048-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5043457-A | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents | ALLERGAN, INC. (US) | 1991-08-27 | — | — | US | disclosed |