Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616293 | 0.82 | ALOX5 (0.44) | FAAHALDH1A1 | |
| SCHEMBL8621126 | 0.82 | ALOX5 (0.44) | FAAHALDH1A1 | |
| SCHEMBL8614770 | 0.78 | ALDH1A1 (0.34) | FAAHALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL9344613 | 0.76 | FAAH (0.43) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL8655608 | 0.75 | HDAC8 (0.41) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL10940544 | 0.75 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL15271899 | 0.75 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL28425391 | 0.75 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL15269112 | 0.75 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL15269043 | 0.75 | KDM4E (0.65) | HDAC8HDAC3HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525002-B1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0525002-A4 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS CA?2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0525002-A1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991016048-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5043457-A | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents | ALLERGAN, INC. (US) | 1991-08-27 | — | — | US | disclosed |