Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25813258 | 0.96 | DHODH (0.74) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL27242987 | 0.96 | DHODH (0.74) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL8619006 | 0.90 | DHODH (0.66) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL8614000 | 0.89 | DHODH (0.68) | DHODHRAB9APTPN1KMT2AMEN1 | |
| SCHEMBL8615187 | 0.89 | DHODH (0.68) | DHODHRAB9APTPN1KMT2AMEN1 | |
| SCHEMBL8614825 | 0.89 | DHODH (0.65) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL9017543 | 0.89 | DHODH (0.65) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL8614827 | 0.88 | DHODH (0.63) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL9017562 | 0.84 | DHODH (0.59) | DHODHTP53MAPK10RAB9AALDH1A1 | |
| SCHEMBL9017616 | 0.84 | DHODH (0.59) | DHODHTP53MAPK10RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | claimed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | claimed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | claimed |
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |