Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27242987 | 0.91 | DHODH (0.74) | DHODHKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL25813258 | 0.91 | DHODH (0.74) | DHODHKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL8615207 | 0.88 | DHODH (0.60) | DHODHKMT2ALMNAHTTTP53 | |
| SCHEMBL8614830 | 0.88 | DHODH (0.69) | DHODHKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL8619006 | 0.85 | DHODH (0.66) | DHODHKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL9017543 | 0.84 | DHODH (0.65) | DHODHKMT2ALMNATP53MAPK10 | |
| SCHEMBL8614825 | 0.84 | DHODH (0.65) | DHODHKMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL9017616 | 0.80 | DHODH (0.59) | DHODHKMT2ALMNATP53MAPK10 | |
| SCHEMBL9017562 | 0.80 | DHODH (0.59) | DHODHTP53MAPK10CYP1A2CYP2C9 | |
| SCHEMBL9310653 | 0.80 | DHODH (0.58) | DHODHKMT2ALMNATP53MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | claimed |
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |