Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 18/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014101 | 0.88 | CCKBR (0.50) | CCKBRMEN1KMT2A | |
| SCHEMBL8615476 | 0.82 | CCKBR (0.46) | CCKBRMEN1KMT2ACCKAR | |
| SCHEMBL9014011 | 0.81 | CCKBR (0.43) | CCKBR | |
| SCHEMBL8622432 | 0.79 | CCKBR (0.59) | CCKBRMEN1KMT2A | |
| SCHEMBL8621950 | 0.78 | CCKBR (0.61) | CCKBR | |
| SCHEMBL7736932 | 0.77 | CCKBR (1.00) | CCKBRCCKAR | |
| SCHEMBL8622444 | 0.77 | CCKBR (0.73) | CCKBRCCKAR | |
| SCHEMBL4424441 | 0.77 | GAA (0.46) | MEN1KMT2A | |
| SCHEMBL8617777 | 0.76 | KDM4E (0.46) | CCKBRMEN1KMT2ACCKAR | |
| SCHEMBL8638391 | 0.76 | CCKBR (0.64) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710229-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-10-21 | — | — | EP | disclosed |
| EP-0558104-B1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO WELLCOME SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| EP-0623118-B1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO WELLCOME SPA (IT) | 1998-05-13 | — | — | EP | disclosed |
| US-5733867-A | CHOLECYSTOKININS AND GASTRIN ANTAGONIST | GLAXO WELLCOME SPA (IT) | 1998-03-31 | — | — | US | disclosed |
| US-5637697-A | ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ | GLAXO SPA (IT) | 1997-06-10 | — | — | US | disclosed |
| US-5580895-A | GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO SPA (IT) | 1996-12-03 | — | — | US | disclosed |
| US-5486514-A | GASTRIN, CHOLECYSTOKININ RECEPTOR ANTAGONISTS | GLAXO SPA (IT) | 1996-01-23 | — | — | US | disclosed |
| EP-0558104-A1 | 1,5-Benzodiazepine derivatives and their use in medicine | GLAXO S.p.A. (IT) | 1993-09-01 | — | — | EP | disclosed |