Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.64 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619442 | 0.86 | LMNA (0.56) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8617937 | 0.85 | PLA2G2A (0.58) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8616485 | 0.83 | LMNA (0.58) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8616019 | 0.83 | KDM4E (0.55) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8620708 | 0.83 | MEN1 (0.68) | KMT2AMEN1TDP1HTTMAPT | |
| SCHEMBL8617058 | 0.82 | LMNA (0.57) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8617678 | 0.82 | ALDH1A1 (0.46) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8617743 | 0.81 | CYP3A4 (0.65) | PDE10AKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8616704 | 0.80 | TACR3 (0.55) | PDE10APLA2G2AKMT2AMEN1TDP1 | |
| SCHEMBL8617544 | 0.80 | MEN1 (0.60) | PDE10AKMT2AMEN1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |