Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387376 | 0.81 | NPC1L1 (0.63) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL11387381 | 0.81 | NPC1L1 (0.63) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL11387387 | 0.81 | NPC1L1 (0.63) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9545735 | 0.81 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9248089 | 0.81 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8616167 | 0.81 | ALDH1A1 (0.43) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8619315 | 0.80 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9384729 | 0.79 | SIGMAR1 (0.39) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9170182 | 0.79 | SIGMAR1 (0.39) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9170189 | 0.79 | SIGMAR1 (0.39) | SIGMAR1ALDH1A1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716948-A | 3-substituted carbacephems | PFIZER INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5665717-A | Carbacephalosporin compound, their preparation and use | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0689540-A1 | CARBACEPHALOSPORIN COMPOUND, THEIR PREPARATION AND USE | PFIZER INC. (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0651755-A1 | CEPHALOSPORINS AND 1-CARBA-1-DETHIA CEPHALOSPORINS | PFIZER INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| EP-0644886-A1 | 3-SUBSTITUTED CARBACEPHEMS | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |
| WO-1994021633-A1 | CARBACEPHALOSPORIN COMPOUND, THEIR PREPARATION AND USE | SMITHKLINE BEECHAM PLC (GB) | 1994-09-29 | — | — | WO | disclosed |
| WO-1994002489-A1 | CEPHALOSPORINS AND 1-CARBA-1-DETHIA CEPHALOSPORINS | SMITHKLINE BEECHAM PLC (GB) | 1994-02-03 | — | — | WO | disclosed |
| WO-1993025551-A1 | 3-SUBSTITUTED CARBACEPHEMS | SMITHKLINE BEECHAM PLC (GB) | 1993-12-23 | — | — | WO | disclosed |