Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | GRM5 | P41594 | 3/20 | 0.53 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.53 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18146062 | 0.89 | SMN1; SMN2 (0.64) | TP53ALDH1A1KCNMA1KMT2AMEN1 | |
| SCHEMBL11731085 | 0.83 | NPC1 (0.56) | TP53KCNMA1KMT2AMEN1KDM4E | |
| SCHEMBL5225094 | 0.82 | KMT2A (0.69) | TP53ALDH1A1JAK2TYK2KCNMA1 | |
| Hydrochloric Acid SCHEMBL30416797 | 0.81 | KMT2A (0.67) | TP53ALDH1A1JAK2TYK2KCNMA1 | |
| SCHEMBL21750984 | 0.81 | RAB9A (0.72) | KMT2AMEN1KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL8618810 | 0.79 | ALDH1A1 (1.00) | TP53ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8311977 | 0.78 | JAK2 (0.73) | TP53ALDH1A1JAK2TYK2KMT2A | |
| SCHEMBL3151420 | 0.78 | KCNMA1 (0.73) | TP53ALDH1A1KCNMA1KMT2AMEN1 | |
| SCHEMBL30171601 | 0.77 | HPGD (0.77) | ALDH1A1KMT2AKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL3365984 | 0.76 | RAB9A (0.83) | TP53KMT2AMEN1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |