Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD4 | Q53EL6 | 2/20 | 0.43 |
| ▸ | GLS2 | Q9UI32 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617164 | 1.00 | PDCD4 (0.43) | PDCD4GLS2ALOX5DAGLANAAA | |
| SCHEMBL9671393 | 0.81 | NAAA (0.42) | NAAAFAAH | |
| SCHEMBL8616760 | 0.80 | PDCD4 (0.42) | PDCD4DAGLA | |
| SCHEMBL9670652 | 0.78 | MCL1 (0.36) | — | |
| Benzene SCHEMBL9328037 | 0.77 | PDCD4 (0.45) | PDCD4GLS2ALOX5DAGLAALDH1A1 | |
| SCHEMBL8653873 | 0.76 | PDCD4 (0.42) | PDCD4GLS2ALOX5DAGLANAAA | |
| SCHEMBL8985076 | 0.76 | PDCD4 (0.47) | PDCD4GLS2ALOX5NAAA | |
| SCHEMBL9671381 | 0.76 | PDCD4 (0.47) | PDCD4GLS2ALOX5NAAA | |
| SCHEMBL7294590 | 0.76 | PDCD4 (0.47) | PDCD4GLS2ALOX5NAAA | |
| SCHEMBL14339054 | 0.76 | PDCD4 (0.47) | PDCD4GLS2ALOX5NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525002-B1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0525002-A4 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS CA?2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0525002-A1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991016048-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5043457-A | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents | ALLERGAN, INC. (US) | 1991-08-27 | — | — | US | disclosed |