Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD4 | Q53EL6 | 2/20 | 0.42 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18196027 | 0.86 | HIF1A (0.50) | HIF1AEPAS1 | |
| SCHEMBL4100839 | 0.86 | HIF1A (0.50) | HIF1AEPAS1 | |
| SCHEMBL1231200 | 0.86 | HIF1A (0.50) | HIF1AEPAS1 | |
| SCHEMBL21434328 | 0.86 | HIF1A (0.50) | HIF1AEPAS1 | |
| SCHEMBL8616611 | 0.80 | PDCD4 (0.43) | PDCD4DAGLA | |
| SCHEMBL8617164 | 0.80 | PDCD4 (0.43) | PDCD4DAGLA | |
| SCHEMBL9745283 | 0.71 | ACHE (0.43) | — | |
| SCHEMBL8614506 | 0.71 | CYP2C19 (0.41) | PDCD4DAGLA | |
| SCHEMBL23322273 | 0.70 | PDCD4 (0.35) | PDCD4DAGLA | |
| SCHEMBL7296014 | 0.70 | PDCD4 (0.47) | PDCD4DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525002-B1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN INC (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0525002-A1 | 2[5H]-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca 2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| WO-1991016048-A1 | 2(5H)-FURANONES SUBSTITUTED IN THE 3 POSITION, AS Ca2+ CHANNEL ANTAGONISTS AND ANTI-INFLAMMATORY AGENTS | ALLERGAN, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5043457-A | 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents | ALLERGAN, INC. (US) | 1991-08-27 | — | — | US | disclosed |