Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620113 | 0.94 | SMN1; SMN2 (0.50) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8616000 | 0.88 | KDM4E (0.58) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8618769 | 0.87 | ALDH1A1 (0.47) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8613492 | 0.87 | ADORA2A (0.44) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8619905 | 0.87 | SMN1; SMN2 (0.42) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8617725 | 0.84 | PDE4A (0.46) | SMN1; SMN2RAB9AALDH1A1NPC1SCNN1A | |
| SCHEMBL8613365 | 0.83 | KDM4E (0.47) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8615315 | 0.83 | KDM4E (0.45) | SMN1; SMN2RAB9AALDH1A1NPC1SCNN1A | |
| SCHEMBL8619003 | 0.83 | SLC40A1 (0.46) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8617911 | 0.82 | SMN1; SMN2 (0.52) | PIK3CASMN1; SMN2RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |