Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | CFD | P00746 | 2/20 | 0.52 |
| ▸ | ELANE | P08246 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18928203 | 0.89 | CFD (0.64) | MAPTMAPK1CFDELANECES2 | |
| SCHEMBL16721009 | 0.86 | MAPT (0.65) | MAPTMAPK1CFDELANEKDM4E | |
| SCHEMBL6403165 | 0.85 | CFD (0.62) | MAPTMAPK1CFDKDM4EHSD17B10 | |
| SCHEMBL18917640 | 0.80 | NPC1 (0.61) | MAPTMAPK1CFDELANEKDM4E | |
| SCHEMBL8003987 | 0.79 | CFD (0.48) | MAPTCFDKDM4EHSD17B10HPGD | |
| SCHEMBL31343490 | 0.79 | CFD (0.48) | MAPTCFDKDM4EHSD17B10HPGD | |
| SCHEMBL27850225 | 0.79 | MAPT (0.72) | MAPTMAPK1ELANEKDM4EHSD17B10 | |
| SCHEMBL8615994 | 0.79 | MAPT (0.72) | MAPTMAPK1ELANEKDM4EHSD17B10 | |
| SCHEMBL27489237 | 0.78 | BACE1 (0.51) | CFDKDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL7658382 | 0.78 | CFD (0.56) | CFDKDM4EALDH1A1TSHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719303-A | USEFUL FOR MEDICALLY TREATING HYPERLIPEMIA | EISAI CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0688325-A1 | PHOSPHONIC ACID DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-12-27 | — | — | EP | disclosed |
| WO-1994020508-A1 | PHOSPHONIC ACID DERIVATIVES | EISAI CO., LTD. (JP) | 1994-09-15 | — | — | WO | disclosed |