Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.51 |
| ▸ | CFD | P00746 | 2/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GGT1 | P19440 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27368090 | 0.89 | BACE1 (0.49) | BACE1CFDCYP4F2CYP4A11ADORA3 | |
| SCHEMBL9754829 | 0.86 | KDM4E (0.44) | CYP4F2CYP4A11KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL28035132 | 0.85 | BACE1 (0.51) | BACE1CFDCYP4F2CYP4A11ADORA3 | |
| SCHEMBL7795580 | 0.82 | PTGS2 (0.48) | BACE1CFDCYP4F2CYP4A11ADORA3 | |
| SCHEMBL11835902 | 0.80 | BACE1 (0.44) | BACE1CFDCYP4F2CYP4A11ADORA3 | |
| SCHEMBL7229895 | 0.80 | CYP1A1 (0.46) | CYP4F2CYP4A11KDM4EALDH1A1HPGD | |
| SCHEMBL7658382 | 0.79 | CFD (0.56) | CFDCYP4F2CYP4A11KDM4EALDH1A1 | |
| SCHEMBL31273249 | 0.78 | BACE1 (0.61) | BACE1ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL28022867 | 0.78 | BACE1 (0.56) | BACE1ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL8617099 | 0.78 | MAPT (0.65) | CFDCYP4F2CYP4A11KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105330541-A | Synthesis method of 4'-halogenated methylbiphenyl-2-formic aid alkyl ester | CHANGZHOU BOSHI WEIYE BIOTECHNOLOGY CO LTD | 2016-02-17 | — | — | CN | disclosed |
| CN-103382154-B | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2015-01-21 | — | — | CN | disclosed |
| CN-103992276-A | 4'-{[(2,4,5-trisubstituted phenyl)-1H-imidazole-1-yl]methyl}biphenyl-2-formic acid derivatives | JILIN INST OF PHARMACEUTICAL RES | 2014-08-20 | — | — | CN | disclosed |
| CN-102212034-B | Method for preparing telmisartan impurity B | WEIHAI DISU PHARMACEUTICAL CO LTD | 2014-02-26 | — | — | CN | disclosed |
| CN-103382154-A | Synthetic method of methyl 4'-bromomethylbiphenyl-2-carboxylate | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2013-11-06 | — | — | CN | disclosed |
| CN-102276585-B | Preparation method for and medicinal usage of 4-substituted-phenyl-aryl-carboxylate derivatives | UNIV CHINA PHARMA | 2013-06-19 | — | — | CN | disclosed |
| CN-102276585-A | Preparation method for and medicinal usage of 4-substituted-phenyl-aryl-carboxylate derivatives | — | 2011-12-14 | — | — | CN | disclosed |
| CN-102212034-A | Method for preparing telmisartan impurity B | WEIHAI DISU PHARMACEUTICAL CO LTD | 2011-10-12 | — | — | CN | disclosed |
| CN-101798287-A | [(4-methyl-2-propyl-N-methoxyl-substituted benzene alkyl-1H-benzimidazole-6-formamide)-1-yl] methyldiphenyl compound and preparation method thereof | BEIJING INST TECHNOLOGY | 2010-08-11 | — | — | CN | disclosed |
| CN-100506799-C | [(2-n-propyl-4-methyl-1H-Benzimidazole)6-radical] carboxamide-1-radical] methylbiphenyl compound, synthesizing method and usage | BEIJING INST TECHNOLOGY (CN) | 2009-07-01 | — | — | CN | disclosed |
| CN-100460396-C | Intermediate of telmisartan, its preparation and use | HANGZHOU SHENGMEI MEDICINE SCI (CN) | 2009-02-11 | — | — | CN | disclosed |
| CN-100441567-C | Acrylic ester and methyl acrylic ester kind side chain type luminous polymer and its synthesis | UNIV SUZHOU (CN) | 2008-12-10 | — | — | CN | disclosed |
| CN-101037414-A | [(2-n-propyl-4-methyl-1H-Benzimidazole)6-radical] carboxamide-1-radical] methylbiphenyl compound, synthesizing method and usage | BEIJING INST TECHNOLOGY (CN) | 2007-09-19 | — | — | CN | disclosed |
| CN-101024631-A | Intermediate of telmisartan, its preparation and use | SHENGMEI MEDICINE SCIENCE TECH (CN) | 2007-08-29 | — | — | CN | disclosed |
| CN-1786106-A | Acrylic ester and methyl acrylic ester kind side chain type luminous polymer and its synthesis | UNIV SUZHOU (CN) | 2006-06-14 | — | — | CN | disclosed |
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |