Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.55 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.55 |
| ▸ | PLG | P00747 | 3/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508883 | 0.88 | ST14 (0.71) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL852367 | 0.87 | F2 (0.58) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851996 | 0.83 | ST14 (0.52) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL8509291 | 0.83 | ST14 (0.52) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL8511550 | 0.83 | ST14 (0.52) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851991 | 0.83 | F2 (0.58) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL852205 | 0.82 | F2 (0.51) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL8512887 | 0.79 | ST14 (0.52) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL8513660 | 0.78 | F2 (0.72) | F2ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851605 | 0.78 | F2 (0.72) | F2ST14PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | F2 112/4885ST14 216/4885PRSS1 3/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | F2 112/4885ST14 216/4885PRSS1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.