Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067698 | 0.77 | NOTUM (0.42) | ALDH1A1MAPTNPC1NOTUMMEN1 | |
| SCHEMBL17883561 | 0.74 | NPC1 (0.41) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL17883702 | 0.72 | BCHE (0.40) | ALDH1A1DRD2DRD3MAPTNOTUM | |
| SCHEMBL11832728 | 0.72 | NOTUM (0.41) | ALDH1A1CYP2D6MAPTNPC1NOTUM | |
| SCHEMBL10388374 | 0.71 | CDC25A (0.43) | ALDH1A1CHRM2MAPTCNR1NPC1 | |
| Hydrochloric Acid SCHEMBL29008070 | 0.71 | NOTUM (0.40) | ALDH1A1CYP2D6MAPTNOTUMMEN1 | |
| SCHEMBL1100574 | 0.69 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2D6CYP2C19CHRM2 | |
| SCHEMBL7708386 | 0.69 | HTR7 (0.51) | ALDH1A1CYP1A2CYP2D6CYP2C19CHRM2 | |
| SCHEMBL861721 | 0.68 | HTT (0.37) | ALDH1A1CYP1A2CYP2D6CYP2C19CHRM2 | |
| Carbamic Acid SCHEMBL15622022 | 0.68 | MEN1 (0.61) | ALDH1A1CHRM2CHRM4CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |
| US-8394828-B2 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | disclosed |
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |
| EP-2308848-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | Janssen Pharmaceutica NV (BE) | 2011-04-13 | — | — | EP | disclosed |
| US-20080300236-A1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | CODD ELLEN | 2008-12-04 | — | — | US | disclosed |
| EP-1603883-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-14 | — | — | EP | disclosed |
| US-20040192728-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-09-30 | — | — | US | disclosed |
| WO-2004069792-A2 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (US) | 2004-08-19 | — | — | WO | disclosed |
| US-20040024209-A1 | 1-Aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents | SCHNUTE MARK E (US) | 2004-02-05 | — | — | US | disclosed |
| EP-1140850-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-0317991-A3 | 1-ARYL-3-QUINOLINE- AND 1-ARYL-3-ISOQUINOLINE-CARBOXAMIDES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4966906-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4966906-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4952588-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-08-28 | — | — | US | disclosed |
| US-4952588-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0317991-A2 | 1-Aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0317991-A2 | 1-Aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4786644-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-22 | — | — | US | disclosed |
| US-4786644-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-22 | — | — | US | disclosed |
| US-4786644-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024209-A1 | 1-Aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, IRF3 | ALDH1A1 668/4885CYP1A2 2494/4885CYP2D6 1779/4885 |
| US-20040192728-A1 | Quinoline-derived amide modulators of vanilloid VR1 receptor | TRPV1, OPRL1, TRPV2 | ALDH1A1 1216/4885CYP1A2 905/4885CYP2D6 1493/4885 |
| US-20080300236-A1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | TRPV1, OPRL1, TRPV2 | ALDH1A1 1216/4885CYP1A2 905/4885CYP2D6 1493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.