Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | FPR3 | P25089 | 2/20 | 0.47 |
| ▸ | TSPO | P30536 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619340 | 0.88 | CRHR1 (0.79) | CRHR1TDP1 | |
| SCHEMBL7215696 | 0.82 | CRHR1 (0.69) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL7222252 | 0.82 | CRHR1 (0.69) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL5599498 | 0.82 | CRHR1 (0.72) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL466243 | 0.82 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL29832078 | 0.82 | CRHR1 (1.00) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL25395568 | 0.81 | CRHR1 (0.98) | CRHR1TDP1FPR3TSPOTMEM97 | |
| Antalarmin SCHEMBL29601552 | 0.81 | CRHR1 (0.98) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL8621371 | 0.81 | CRHR1 (0.67) | CRHR1TDP1 | |
| SCHEMBL6295510 | 0.75 | CRHR1 (0.69) | CRHR1FPR3TSPOTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998045295-A1 | CERTAIN PYRROLOPYRIDINE DERIVATIVES; NOVEL CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-10-15 | — | — | WO | claimed |
| WO-1998045295-A1 | CERTAIN PYRROLOPYRIDINE DERIVATIVES; NOVEL CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |