SCHEMBL8621371

SCHEMBL8621371

CCCN(CC1CC1)c1cc(C)nc2c1c(C)c(C)n2-c1c(C)cc(C)cc1C

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 14/20 0.67
TDP1 Q9NUW8 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8619340 0.89 CRHR1 (0.79) CRHR1TDP1
SCHEMBL7217860 0.84 CRHR1 (0.49) CRHR1
SCHEMBL7222478 0.83 CRHR1 (0.55) CRHR1
SCHEMBL8617375 0.81 CRHR1 (1.00) CRHR1TDP1
SCHEMBL7217519 0.73 CRHR1 (0.53) CRHR1TDP1
SCHEMBL6801666 0.72 CRHR1 (0.53) CRHR1
SCHEMBL7215931 0.71 CRHR1 (0.57) CRHR1TDP1
SCHEMBL7222161 0.71 CRHR1 (0.50) CRHR1
SCHEMBL5786584 0.70 CRHR1 (0.64) CRHR1
SCHEMBL3618790 0.70 CRHR1 (0.51) CRHR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998045295-A1 CERTAIN PYRROLOPYRIDINE DERIVATIVES; NOVEL CRF1 SPECIFIC LIGANDS NEUROGEN CORPORATION (US) 1998-10-15 WO claimed