Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618668 | 0.87 | SMO (0.43) | KDM4EMAPTSMN1; SMN2STAT6HIF1A | |
| Hydrochloric Acid SCHEMBL8615174 | 0.86 | SMO (0.42) | KDM4EMAPTSMN1; SMN2STAT6HIF1A | |
| SCHEMBL8614057 | 0.81 | MAPT (0.38) | KDM4EMAPTSMN1; SMN2NUDT1STAT6 | |
| SCHEMBL8620636 | 0.73 | NPC1 (0.49) | KDM4ESMN1; SMN2STAT6HTTHIF1A | |
| SCHEMBL8619835 | 0.73 | SMO (0.49) | SMN1; SMN2HTTNPSR1LMNAALDH1A1 | |
| SCHEMBL8616307 | 0.71 | SMO (0.43) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL8616502 | 0.70 | KDM4E (0.48) | KDM4EMAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL8617949 | 0.69 | SMO (0.46) | KDM4ESMN1; SMN2STAT6HIF1ALMNA | |
| SCHEMBL8620870 | 0.69 | SRC (0.47) | NUDT1LMNAKDRAURKALCK | |
| SCHEMBL8614046 | 0.69 | SMO (0.49) | SMN1; SMN2HTTNPSR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |