Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435072 | 0.94 | TSHR (0.39) | TSHRALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL1972697 | 0.80 | CCNE1 (0.32) | CCNE1CDK2GSK3B | |
| SCHEMBL7959793 | 0.80 | TSHR (0.37) | TSHRALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL26696803 | 0.79 | CNR2 (0.33) | TSHRCCNE1CDK2GSK3B | |
| SCHEMBL1159435 | 0.79 | MAPT (0.41) | TSHRALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL10671268 | 0.78 | ALDH1A1 (0.41) | TSHRALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL12224351 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1L3MBTL1ATM | |
| SCHEMBL16009191 | 0.76 | CTSK (0.42) | SMN1; SMN2 | |
| SCHEMBL4020424 | 0.76 | ALDH1A1 (0.37) | TSHRALDH1A1 | |
| SCHEMBL15260667 | 0.75 | TSHR (0.36) | TSHRALDH1A1POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833637-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0833637-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040136-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |