Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618022 | 0.80 | TSHR (0.38) | CCNE1CDK2GSK3B | |
| SCHEMBL7435072 | 0.75 | TSHR (0.39) | CCNE1CDK2GSK3BCNR2 | |
| SCHEMBL29535838 | 0.75 | POLB (0.45) | — | |
| SCHEMBL6820687 | 0.74 | POLB (0.44) | — | |
| SCHEMBL1972696 | 0.73 | POLB (0.41) | — | |
| SCHEMBL26696803 | 0.72 | CNR2 (0.33) | CCNE1CDK2GSK3BCNR2 | |
| SCHEMBL16009191 | 0.69 | CTSK (0.42) | — | |
| SCHEMBL4020424 | 0.68 | ALDH1A1 (0.37) | CNR2 | |
| SCHEMBL30155362 | 0.68 | SIGMAR1 (0.36) | — | |
| SCHEMBL14930639 | 0.68 | USP2 (0.42) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404693-B2 | Substituted piperidine compounds and methods of their use | ADOLOR CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-20110144108-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144108-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND METHODS OF THEIR USE | OPRM1, OPRK1, OPRD1 | CCNE1 4739/4885CDK2 2156/4885GSK3B 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.