Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619999 | 0.88 | HRH4 (0.61) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8624871 | 0.85 | HRH4 (0.57) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11662294 | 0.81 | HRH3 (0.44) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8805366 | 0.78 | HRH4 (0.63) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8621926 | 0.78 | HRH3 (0.60) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| Clobenpropit SCHEMBL49050 | 0.77 | HRH4 (1.00) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8619886 | 0.77 | HRH4 (0.61) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8625836 | 0.76 | HRH3 (0.63) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8620794 | 0.74 | HRH3 (0.56) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8624777 | 0.72 | TBXAS1 (0.36) | HRH3HRH4TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | claimed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | claimed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | claimed |
| US-5837718-A | ANTIHISTAMINES | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1998-11-17 | — | — | US | disclosed |
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | disclosed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | disclosed |