Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.36 |
| ▸ | COMT | P21964 | 2/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770691 | 0.72 | MAPT (0.50) | ALDH1A1MAPTSMN1; SMN2CXCR4SCN1A | |
| SCHEMBL13978036 | 0.68 | CYP2D6 (0.42) | ALDH1A1TDP1L3MBTL1LMNAMAPT | |
| SCHEMBL31006317 | 0.68 | HTR6 (0.61) | ALDH1A1LMNAMAPTHTT | |
| SCHEMBL9810195 | 0.66 | DDB1 (0.40) | CXCR4 | |
| Hydrochloric Acid SCHEMBL10569209 | 0.65 | CXCR4 (0.40) | CXCR4 | |
| SCHEMBL2688968 | 0.65 | HDAC1 (0.45) | CXCR4HDAC1HDAC6 | |
| SCHEMBL29640806 | 0.65 | HDAC1 (0.45) | CXCR4HDAC1HDAC6 | |
| SCHEMBL5021376 | 0.65 | P2RX7 (0.45) | CXCR4HDAC1HDAC6 | |
| SCHEMBL12833464 | 0.65 | HDAC1 (0.41) | CXCR4HDAC1HDAC6 | |
| SCHEMBL10286357 | 0.65 | P2RX7 (0.45) | CXCR4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789587-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1998-08-04 | — | — | US | disclosed |
| US-5606054-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1997-02-25 | — | — | US | disclosed |
| WO-1995016692-A1 | HETEROCYCLIC-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | disclosed |